This is an autoimmune skin disease and is sometimes triggered by medications. Blisters and hives develop on the skin, especially on the arms, legs, lower back and/or buttocks. Linear IgA disease: A rare chronic skin disease characterized by the development of groups of itchy skin blisters and raised lesions (papules) It is not associated with gluten sensitivity. The differential diagnosis of DH includes many itchy and blistering disorders such as: Symptomatic patients may present with abdominal bloating, cramping, pain, diarrhea, or constipation. DH patients generally have less gastrointestinal symptoms than patients with CD. Patients with DH can rarely develop oral ulcerations (canker sores).ĭH is a skin manifestation of CD and virtually every patient has gluten sensitivity causing inflammation and damage to the small intestine. Tooth enamel defects found in CD such as horizontal grooves, pits, or discoloration may occur in patients with DH. The face and groin are less frequently involved. The most common sites for lesion development are the elbows, knees, buttocks, and scalp. Itching and burning may be almost intolerable and the need to scratch may become irresistible. The classic finding of DH is the development of intensely itchy blisters, and red raised skin lesions that occur in groups. This autoimmune disease may cause skin, oral and/or gastrointestinal manifestations related to gluten-sensitivity. Stay Informed With NORD’s Email Newsletter.Find a Rare Disease Patient Organization.Find Clinical Trials & Research Studies.Launching Registries & Natural History Studies.A Podcast For The Rare Disease Community.
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